Due to social factors, some communities face more stark health disparities and greater barriers to health. The majority of our community-engaged initiatives focus on Louisville communities that experience the effects of social and health disparities. We also have several studies, both completed and ongoing, on health literacy. The first was a series of focus groups on health insurance and health systems literacy. The second was a series of community-based participatory research projects, called “Boot Camp Translations,” on particular health conditions, including depression, HIV, and childhood asthma. These projects led to the development multifaceted health communication campaigns. Additionally, our team is currently seeking to understand health issues that affect LGBTQ adolescents in order to improve health policies and practices in Louisville and, in turn, enhance their health experiences and outcomes.